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These hormones control the production and release of eggs from the ovary. This medicine is used in the management of female infertility. Menotropins (men-oh-TROE-pins ) are a mixture of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) that are naturally produced by the pituitary gland.

Use in females - FSH is primarily responsible for stimulating growth of the ovarian follicle, which includes the developing egg, the cells surrounding the egg that produce the hormones needed to support a pregnancy, and the fluid around the egg. As the follicle grows, an increasing amount of the hormone estrogen is produced by the cells in the follicle and released into the bloodstream. Estrogen causes the endometrium (lining of the uterus) to thicken before ovulation occurs. The higher blood levels of estrogen will also tell the hypothalamus and pituitary gland to slow the production and release of FSH.

Use in males - Menotropins are used to stimulate the production of sperm in some forms of male infertility.

Special precautions

Allergies - tell your doctor if you have ever had any unusual or allergic reaction to menotropins. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - if you become pregnant as a result of using this medicine, there is an increased chance of a multiple pregnancy.

Breast-feeding - It is not known whether menotropins pass into breast milk. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children - Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of menotropins in children with use in other age groups.

Older adults - many medicines have not been studied specifically in older people. Therefore, it may not be know whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of menotropins in the elderly with use in other age groups.

Other medicines - although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems - the presence of other medical problems may affect the use of menotropins. Make sure you tell your doctor if you have any other medical problems, especially:

• Adrenal gland or thyroid disease (not controlled) or

• Tumor, brain or

• Tumor, sex hormone-dependent - Menotropins should not be used in patients with these medical problems.

• Cyst on ovary - Menotropins can cause further growth of cysts on the ovary

• Primary ovarian failure - Menotropins will not work in patients whose ovaries no longer develop eggs.

• Unusual vaginal bleeding - Some irregular vaginal bleeding is a sign that the endometrium is growing too rapidly, possibly of endometrial cancer, or some hormone imbalances; the increases in estrogen production caused by menotropins can make these problems worse. If a hormonal imbalance is present, it should be treated before beginning menotropins therapy

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• For females only

• More common

  • Bloating (mild);  pain, swelling, or irritation at place of injection;  rash at place of injection or on body;  stomach or pelvic pain 

Less common or rare

• Abdominal or stomach pain (severe);  bloating (moderate to severe);  decreased amount of urine;  feeling of indigestion;  nausea, vomiting, or diarrhea (continuing or severe);  pelvic pain (severe);  shortness of breath;  swelling of the lower legs;  weight gain (rapid) 

• For males only

  • More common

    • Dizziness;  fainting;  headache;  irregular heartbeat;  loss of appetite;  more frequent nosebleeds;  shortness of breath 

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if the following side effect continues or is bothersome:

• For females only

  • More common

    • Coughing;  headache;  mild nausea;  sneezing;  sore throat;  stuffy or runny nose 

• For males only

  • Less common

    • Enlargement of breasts 

• For females only

  • Abdominal or stomach pain (severe);  bloating (moderate to severe);  decreased amount of urine;  feeling of indigestion;  nausea, vomiting, or diarrhea (continuing or severe);  pelvic pain (severe);  shortness of breath;  weight gain (rapid) 

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Keep all appointments with your doctor.

Don’t let anyone else take your medicines.